The global peripheral nerve injury market was estimated at USD 1.55 billion in 2022 and it is expected to surpass around USD 3.26 billion by 2032, poised to grow at a CAGR of 7.73% from 2023 to 2032. The peripheral nerve injury market in the United States was accounted for USD 291.2 million in 2022.
Key Pointers
- North America region dominated the market with the largest market share of 31% in 2022.
- Asia Pacific is expected to register the highest CAGR during forecast period.
- By Product, the nerve conduit segment contributed the largest market share of 42% in 2022.
- By Product, the nerve wraps segment is expected to grow at the fastest CAGR during forecast period.
- By Surgery, the direct nerve repair segment generated the maximum market share of 54% in 2022.
- By Application, the upper extremities segment registered the maximum market share of 78% in 2022
The peripheral nerve injury market is a multifaceted sector within the broader healthcare landscape, addressing disorders affecting the peripheral nervous system. This market encompasses a spectrum of conditions, ranging from traumatic injuries to neuropathies, presenting a dynamic landscape for pharmaceutical and medical device advancements.
Market Growth
The growth of the peripheral nerve injury market is propelled by several key factors. Firstly, the escalating incidence of traumatic injuries, surgical complications, and medical conditions resulting in peripheral nerve damage has created a pressing demand for effective treatment options. This surge in cases has stimulated substantial investments in research and development by pharmaceutical and medical device companies. Secondly, advancements in diagnostic technologies, including sophisticated imaging techniques and electrophysiological studies, have significantly enhanced the precision and speed of peripheral nerve injury diagnosis. This improvement facilitates early intervention and treatment planning, positively impacting patient outcomes. Furthermore, ongoing innovation in therapeutic approaches, such as regenerative medicine and neuroprotective agents, is contributing to the expansion of treatment options. Collaborative research initiatives, increased healthcare investments, and a focus on addressing unmet medical needs collectively underscore the positive trajectory of the Peripheral Nerve Injury Market.
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Report Scope of the Peripheral Nerve Injury Market
| Report Coverage | Details |
| Market Revenue by 2032 | USD 3.26 billion |
| Growth Rate from 2023 to 2032 | CAGR of 7.73% |
| Revenue Share of North America in 2022 | 31% |
| Base Year | 2022 |
| Forecast Period | 2023 to 2032 |
| Market Analysis (Terms Used) | Value (US$ Million/Billion) or (Volume/Units) |
Market Dynamics
Drivers
Increasing Incidence of Peripheral Nerve Injuries:
The market is being driven by a notable rise in the prevalence of peripheral nerve injuries, stemming from factors such as traumatic incidents, surgical procedures, and underlying medical conditions. This surge in cases has intensified the demand for innovative and effective treatment solutions.
Advancements in Diagnostic Technologies:
Technological progress in diagnostic tools, including advanced imaging techniques and electrophysiological studies, has significantly enhanced the accuracy and speed of peripheral nerve injury diagnosis. This, in turn, facilitates prompt intervention and tailored treatment planning for better patient outcomes.
Restraints
Long-Term Clinical Data Requirements:
The demand for robust, long-term clinical data presents a hurdle in the development and approval of peripheral nerve injury treatments. Demonstrating the sustained efficacy and safety of interventions over extended periods adds complexity and time to the regulatory process.
High Development Costs:
The research and development of innovative treatments for peripheral nerve injuries involve substantial costs. High development expenses, coupled with uncertain market outcomes and potential reimbursement challenges, can deter investment in this specialized area.
Opportunities
Personalized Treatment Approaches:
The increasing emphasis on personalized medicine opens avenues for tailored treatment strategies. Individualized approaches, considering patient-specific factors, can lead to more effective and targeted interventions, potentially improving overall outcomes for individuals with peripheral nerve injuries.
Regenerative Medicine and Stem Cell Therapies:
The growing focus on regenerative medicine and stem cell therapies offers a significant opportunity for the development of novel treatments. These approaches hold promise for enhancing nerve regeneration and functional recovery, addressing a critical aspect of peripheral nerve injury management.
Product Insights
The nerve conduit led the market with the revenue share of 42% in 2022. This can be attributed to technological advancements, a wide range of applications, and government funding for innovations. Depending on the conduit material and manufacturing process, nerve conduits are of two types: biological and synthetic nerve conduits. Advanced products, such as biodegradable polymers, are expected to enhance spinal stabilization, heal fractures, and reduce hospitalization. Another instance of advancement is the development of stimuli-responsive biomaterials to achieve a feedback system for better integration and regeneration of tissues. Therefore, due to such key factors, the segment is expected to grow.
Moreover, the use of nerve conduits, a viable replacement for nerve autografts, is now restricted to peripheral nerves with modest abnormalities and small diameters. Investments by key companies to develop more effective products are likely to propel market growth in the coming years. For instance, in April 2022, a significant U.S. marketing campaign for Toyobo Co., Ltd.’s Nerbridge TM nerve conduit for peripheral nerve regeneration began
As a result, this market is anticipated to grow. The nerve wraps segment is anticipated to grow at the fastest CAGR from 2023 to 2032 due to high demand as nerve wraps prevent scar tissue ingrowth, minimize the potential for nerve entrapment, and guide regenerating nerve fibers as compared to other products. Furthermore, market participants are currently offering cutting-edge products that enhance treatment effectiveness. For instance, in July 2022, researchers at Northwestern University created a stretchable device wrap that could be used to wrap the nerves to reduce pain without using medicines, such as opioids.
Surgery Insights
The direct nerve repair segment led the global market with the largest market share of 54% in 2022. Around 20 million people in the U.S. suffer from PNIs, usually caused by trauma or medical disorders. Direct nerve repair is used for the treatment of peripheral nerve injuries. It is considered a gold-standard surgical treatment for severe injuries. These injuries lead to loss of ability to communicate due to malfunction of motor & sensory nerves between the peripheral organs and the Central Nervous System (CNS), resulting in impairment. Furthermore, organizations promote R&D for product development, which is expected to spur market growth.
For instance, in April 2023, scientists from the University of Oxford and MedUni Vienna demonstrated that nerve damage can be effectively repaired by using tubes made of a combination of silk from spiders and silkworms. The researchers used two distinct kinds of natural silk to create a novel kind of nerve guide. Silkworms created the tube wall, and dragline silk strands from spiders filled the interior of the tube. Rats with a ruptured nerve in their sciatica resulting in a 10 mm gap were used to test the tubes.
The stem cell therapy segment is anticipated to witness the fastest CAGR from 2023 to 2032. Stem cells are perceived as the backbone of regenerative medicine wherein dynamic research activities are carried out. There are approximately 2,754 (2021) and 570 (2016) clinics in the U.S. that provide stem cell therapy, with the number likely to expand. A stem cell injection can cost anything from USD 8,000 to 30,000. Although many of these do not follow FDA regulations, they have been proven to be effective in the treatment of several conditions. The FDA has recommended that these cells be controlled like drugs because of the safety concerns raised by this situation. As a result, clinics may expect more stringent approval procedures in the future.
Application Insights
The upper extremities segment contributed the largest share of 78% in 2022 and is anticipated to grow further at the fastest CAGR from 2023 to 2032. PNIs in the upper extremity are extremely common. Peripheral nerves are also damaged due to compression injuries. For instance, recurrent & severe carpal and cubital tunnel syndrome instances can lead to problems and PNI, necessitating surgical intervention and peripheral nerve protection. The “Upper Extremity Compression” is PNI brought on by recurring cubital tunnel and carpal tunnel syndrome.
However, manufacturers, for instance, have helped surgeons with their needs for healing damaged or transected peripheral nerves. Axogen develops new and next-generation devices. According to Axogen, there are still opportunities to create or buy complementing products for peripheral nerve healing. In addition, there are prospects to broaden the current product line through additional peripheral nerve repair procedures in urology, head and neck surgery, lower extremity surgery, and the surgical management of pain.
Regional Insights
North America accounted for the largest share of 31% in 2022 due to the high prevalence of PNIs coupled with growing geriatric population in the region. The geriatric population is highly susceptible to these disorders. In addition, a rise in government funding and initiatives for raising awareness about PNIs is expected to drive regional market growth. Moreover, one of the main variables influencing regional market growth is technological progress due to industry leaders’ active involvement in the launch of new, more effective products. For instance, in March 2022, Integra LifeSciences launched a resorbable implant product to fix discontinuities in peripheral nerves, the NeuraGen 3D Nerve Guide Matrix.
NeuraGen 3D is a nerve healing device designed to provide an optimal environment that, when compared to hollow nerve conduits alone, may facilitate a more fully functional recovery after mid-gap nerve repair. Asia Pacific is expected to register the highest CAGR during forecast period. Rising cases of PNIs coupled with an unmet need for effective and long-term treatment solutions are expected to present significant growth opportunities for the regional market.
Key Companies
- AxoGen, Inc.
- Stryker
- Baxter International, Inc.
- Polyganics BV
- Integra Lifesciences Corporation
- Renerva, LLC
- Medovent GmbH
- Toyobo Co., Ltd.
Peripheral Nerve Injury Market Report Segmentations:
By Product
- Nerve Conduit
- Nerve Protector
- Nerve Connector
- Nerve Wraps
By Surgery
- Direct Nerve Repair
- Nerve Grafting
- Stem Cell Therapy
By Application
- Upper Extremities
- Lower Extremities
By Region
- North America
- Europe
- Asia Pacific
- Latin America
- Middle East & Africa
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